20S Proteasome activator 1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

20S Proteasome activator 1 是一种有效的 20S 蛋白酶激活剂，对胰蛋白酶样位点、胰凝乳蛋白酶样位点和半胱天冬酶位点的 IC50 分别为 0.3 μM、0.7 μM 和 1.8 μM。20S Proteasome activator 1 能在细胞系统中翻译，防止致病性 α-synuclein A53T 突变体积累。20S Proteasome activator 1 可用于神经退行性疾病的研究。

20S Proteasome activator 1 is a potent 20S proteasome activator with EC200 values of 0.3 μM, 0.7 μM and 1.8 μM for trypsin-like site, chymotrypsin-like site and caspase-like site. 20S Proteasome activator 1 translates well in a cellular system, preventing the accumulation of the pathogenic A53T mutant of α-synuclein. 20S Proteasome activator 1 can be used for researching neurodegenerative diseases.

20S Proteasome activator 1 (compound 19) (2.5-15 μM; 45 min) degrades 73% α-synuclein at 10 μM, and over 80% at 15 μM.20S Proteasome activator 1 (5-15 μM; 24 h) reduces 25% A53T mutant, and dose-dependently reduces enhancement of α-synuclein in Hek-293T cells (transiently transfected with an A53T mutant α-synuclein plasmid) at 5 μM; decreases 67% A53T α-synuclein at 15 μM.

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Proteasome/Ubiquitin

Proteasome

Proteasome

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2761578-18-9

492.97

C27H19ClF2N2OS

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (202.85 mM; 超声助溶 )

C(CC(N(C1=CC=C(F)C=C1)C2=CC=C(F)C=C2)=O)N3C=4C(SC=5C3=CC=CC5)=CC=C(Cl)C4

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(-20℃)

With Ice Pack

≥ 2 years